Scientist, Immunology Cell Therapy Discovery at AstraZeneca

Scientist Immunology Cell Therapy DiscoveryWaltham MA USAAstraZeneca is a science-led biopharmaceutical company focused on transforming patient outcomes. We seek a curious collaborative Scientist to advance novel cell therapies for autoimmune and other immunology indications. This role spans both in vitro and in vivo work and requires strong cross-functional collaboration.Role overviewYou will design and execute in vitro functional assays and in vivo studies in autoimmune disease models; integrate internal and external data to identify and validate targets and modalities; and generate critical data to efficiently move programs from discovery toward translation.Key responsibilitiesIn vivo studies: Plan and run autoimmune or inflammatory disease models including study design dosing/engraftment and tissue collection and data analysis in partnership with in vivo pharmacology.In vitro discovery: Identify and validate cell therapy targets and characterize functional activity of engineered cell therapies; connect in vitro and in vivo findings.Data and analytics: Apply a rigorous data-driven approach to experimental design and decision-making; use appropriate analytics and visualization.Cross-functional collaboration: Work with protein engineering genomics translational science clinical and CMC to align objectives coordinate experimental activites and deliver milestones.Team and communication: Document work to high standards; present results to teams and leaders; support and mentor colleagues to foster a productive lab environment.Required qualifications and skillsEducation: MS with 3 years; or BS with 5 years experience in immunology autoimmunity cell therapy or a related field (industry experience strongly preferred).In vitro expertise: Primary human cell culture and functional cell-based assays; multicolor flow cytometry; multiplex cytokine detection; assay development.In vivo expertise: Hands-on planning oversight and execution including animal handling and dosing/engraftment of murine in vivo studies; experience with autoimmune disease models humanized mouse models and/or tumor xenograft models.Data proficiency: Strong experimental design analysis and interpretation; proficiency with common analysis tools such as FlowJo and Prism.Working style: Demonstrated independence in a dynamic environment excellent record-keeping and reliable delivery to timelines.Communication: Clear concise written and verbal communication.Desired qualifications and skillsAutoimmunity and/or inflammation experience: Familiarity with in vitro and in vivo model systems for conditions such as rheumatoid arthritis ankylosing spondylitis psoriatic arthritis inflammatory bowel disease COPD fibrosis etc.Industry background: Experience in pharmaceutical/biotech drug discovery and development.Cell therapy experience: Work with engineered cell products (e.g. T cell subsets CAR-based modalities); familiarity with novel CAR or antibody target discovery.The annual base pay (or hourly rate of compensation) for this position ranges from $87000 to $130800. Hourly and salaried non-exempt employees will also be paid overtime pay when working qualifying overtime hours. Base pay offered may vary depending on multiple individualized factors including market location job-related knowledge skills and addition our positions offer a short-term incentive bonus opportunity; eligibility to participate in our equity-based long-term incentive program (salaried roles) to receive a retirement contribution (hourly roles) and commission payment eligibility (sales roles). Benefits offered included a qualified retirement program 401(k) plan; paid vacation and holidays; paid leaves; and health benefits including medical prescription drug dental and vision coverage in accordance with the terms and conditions of the applicable plans. Additional details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired employee will be in an at-will position and the Company reserves the right to modify base pay (as well as any other discretionary payment or compensation program) at any time including for reasons related to individual performance Company or individual department/team performance and market factorsDate Posted09-Dec-2025Closing Date29-Dec-2025Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and furtherance of that mission we welcome and consider applications from all qualified candidates regardless of their protected characteristics. If you have a disability or special need that requires accommodation please complete the corresponding section in the application form. Key Skills Laboratory Experience,Immunoassays,Machine Learning,Biochemistry,Assays,Research Experience,Spectroscopy,Research & Development,cGMP,Cell Culture,Molecular Biology,Data Analysis Skills Employment Type : Full-Time Experience: years Vacancy: 1 Hourly Salary Salary: 87000 - 130800