Analytical Development Principal Research Associate at Vertex Pharmaceuticals

Job DescriptionEmployer: Vertex Pharmaceuticals IncorporatedJOB TITLE: Analytical Development Principal Research AssociateLOCATION: 316 Northern Ave. Boston MA 02210OPENINGS: 1DUTIES: Design develop execute and analyze characterization and release assays for identity purity strength and potency of cell- based products. Multiple analytical platforms will be employed including RT-qPCR SDS-PAGE ELISA Western blots Flow cytometry Flow-cam ddPCR Alphalisa and cell- based functional/ potency assays.Execute test methods in support of pluripotent stem cell Process Development activities.Troubleshoot optimize and trend assay performance.Report on project progress write analytical development protocols and reports provide recommendations to management.Identify qualify and manage analytical reagents as per regulatory standards.Establish assay design criteria using Design of Experiments (DOE) and other contemporary development tools.Perform statistical analysis to establish specificity sensitivity linear range precision and accuracy of test methods.Establish reference standard materials as required to support assay validation.Transfer assays to QC and provide SME support for assay qualification author transfer/qualification protocols and reports.Maintain excellent written documentation (e.g. lab notebook and test forms).REQUIREMENTS: Employer will accept a Masters degree in Biochemistry Cell & Molecular Biology Pharmacology and Toxicology or a related field and 2 years of experience in the job offered or in an Analytical Development Principal Research Associate-related occupation.Alternatively employer will accept a Bachelors degree in Biochemistry Cell & Molecular Biology Pharmacology and Toxicology or a related field and 6 years of experience in the job offered or in an Analytical Development Principal Research Associate-related occupation.Position requires demonstrable experience in the following:Developing analytical methods in compliance with ICH guidelines. Assisting with the following assay platforms: RT-qPCR ELISA Western blots Flow cytometry or cell- based functional/ potency assays. Assisting with the culture of multiple mammalian cell types and combination drug product (Cells device) Using literature to design proof of concept studies. Writing technical documents including development reports qualification protocols and qualification reports.Rate of Pay: $88300.00 - $132400.00CONTACT: Send Resume to . Reference 12140.579. EOE.#LI-DNIPay Range:$0 - $0Disclosure Statement:The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors including skills competencies experience and other job-related factors permitted by law.At Vertex our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career financial family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter) educational assistance programs including student loan repayment a generous commuting subsidy matching charitable donations 401(k) and so much more.Flex Designation:On-Site DesignatedFlex Eligibility Status:In this On-Site designated role you will work five days per week on-site with ad hoc flexibility.Note: The Flex status for this position is subject to Vertexs Policy on Flex @ Vertex Program and may be changed at any time.#LI-OnsiteCompany InformationVertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a persons race color sex gender identity or expression age religion national origin ancestry ethnicity disability veteran status genetic information sexual orientation marital status or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager or contact Talent Acquisition at Required Experience:Staff IC Key Skills Laboratory Experience,ELISA,Immunoassays,Mammalian Cell Culture,Biochemistry,Cell Biology,Research Experience,Cell Culture,Molecular Biology,Microscopy,Research Laboratory Experience,Western Blot Employment Type : Full-Time Experience: years Vacancy: 1 Monthly Salary Salary: 88300 - 132400