Bioinformatics Engineer at Manifold Bio

Manifold Bio is a dynamic biotech company building a pipeline of targeted biologics using a novel in vivo-centric discovery approach. Our drug discovery engine is differentiated by massively parallel screening in vivo from the beginning of our discovery process. This unique platform is powered by a proprietary protein barcoding technology that allows multiplexed protein quantitation at unprecedented scale and sensitivity. We combine this and other high-throughput protein engineering approaches with computational design to create antibody-like drugs and other biologics. Our world-class team of protein engineers biologists and computational scientists are working together to aim the platform at therapeutic opportunities where precise targeting is the key to overcoming clinical challenges.PositionManifold Bio is seeking an exceptional Bioinformatics Engineer to join our growing team. In this role you will work closely with computational and experimental scientists to build core infrastructure and extract insights from our Next Generation Sequencing readouts as part of our platforms Compute team. Within the Compute team you will engineer advanced DNA barcode sequence counting algorithms and associated infrastructure to support a wide variety of assay read-outs and modalities including phage display yeast display and DNA barcode counting (MPRAs). Future projects may include RNA-seq scRNA-seq Whole Genome Sequence (WGS) and more so familiarity with these is a plus. This position will also be responsible for refining and deploying the data pipelines as self-serve workflows for the wet lab scientists so familiarity with workflow orchestrators/engines is additionally a plus. Library-based research is central to our research at Manifold and this role will have a deep impact across our entire workflow.ResponsibilitiesRefine and improve central Python NGS infrastructureImplement advanced counting algorithms for Illumina and Oxford Nanopore sequencing readoutsSupport custom bioinformatics projects such as RNA-seq and scRNA-seq experimentsDeploy bioinformatics data pipelines as self-serve workflows for wet lab scientistsSupport in NGS data management of dozens of terabytes of raw dataRequired QualificationsPhD in computational biology or bioinformatics or B.S. with 7 years of equivalent experience in computational biology or bioinformaticsExperience working with Next Generation Sequencing (NGS) data from library-based experimentsStrong Python development skillsExperience with translating and scaling local workflows onto AWSDeep knowledge of version control test-driven development and cloud computingExperience working with workflow orchestrators/enginesStrong understanding of statistics fundamentals and data analysis methodologiesOutstanding written and verbal communication skills for cross-functional collaborationPreferred QualificationsIndustry experience in antibody therapeutic development or biotechnology R&DExperience building and supporting custom single cell sequencing workflowsExperience with robust code package development CI/CDTrack record of developing computational tools or pipelines adopted by experimental teamsExperience mentoring junior scientists or leading cross-functional project teamsPublications or patents in antibody engineering protein design or high-throughput screening methodsFamiliarity with cloud computing platforms (AWS GCP) and containerization technologiesExperience with Tableau and other data visualization packagesThis Role Might Be Perfect For You IfYou thrive in collaborative environments where computational insights directly guide experimental decisionsYoure energized by translating complex datasets into actionable recommendations for drug discovery teamsYou enjoy building robust production-quality tools that others rely on for critical decisionsYoure passionate about the therapeutic potential of engineered antibodies and want to accelerate their developmentYou love working at the intersection of cutting-edge computational methods and innovative experimental platformsWe value different experiences and ways of thinking and believe the most talented teams are built by bringing together people of diverse cultures genders and backgrounds. Key Skills ASP.NET,Health Education,Fashion Designing,Fiber,Investigation Employment Type : Full Time Experience: years Vacancy: 1