Computational Associate II Neurobiology and Therapeutics of Psychiatric Disorders at The Broad Institute

General information Location Cambridge MA Ref # 43318 Job Family Research Workplace Hybrid Date published 11/21/2025 Time Type Full time Pay Range 58000/yr - 80667 Usd Annual Description & Requirements We are seeking a motivated Computational Associate II to join the Sheng research group in the Stanley Center for Psychiatric Research at the Broad Institute of MIT and Harvard.This group investigates the neurobiological mechanisms of schizophrenia and bipolar disorder using mouse models with strong human-genetic validity. This candidate will collaborate with biologists and geneticists to analyze data across multiple modalities including transcriptomics proteomics high-content behavioral assays and functional ultrasound imagingwith the goal of identifying convergent and divergent patterns and molecular signatures that shed light on the mechanisms and circuits disrupted in mental illness.This person will apply existing computational methods help develop new computational methods where needed and interpret results within a biological context. This researcher will work in close collaboration with laboratory scientists on analysis of a range of projects with a strong emphasis on bulk single cell and spatial RNA-seq approaches. The scope will include integration with other internal and external genomics datasets. The position will provide an opportunity to become a part of the computational biology community at the Broad Institute.CHARACTERISTIC DUTIESAnalyze large RNA-Seq datasets to profile transcriptomes from brain and neuronal cell populations and interpret results to derive important biological insights into these models.Work with wet-lab biologists to design and implement appropriate experiments for future computational analysis.Provide results in formats accessible to a research community of biologists and geneticists.Develop apply document and maintain computational tools both for own use and to support analysis by biologist colleagues without formal computational training.Follow relevant scientific literature to ensure use of optimal methods and understand emerging practices across the field.Contribute to reports and papers for presentation and publication and present at scientific conferences as appropriate.Regularly attend and present results at team meetings to share results plan projects and experiments.Work with other Broad computational biologists experienced with RNA-Seq to learn discuss and integrate the most appropriate solution for an experiment or project.REQUIREMENTSBS with 3 years of related experience or MS in Bioinformatics Computer Science or other relevant scientific discipline with 1 years of related experience.Experience working with RNAseq data.Should have a demonstrated proficiency in R and/or Python or related languages.Experience with and solid understanding of statistical analysis is required.Familiarity with next-generation sequence data analysis tools particularly those for RNA-seqUnderstanding of molecular biology and next generation sequencing is highly preferred.Familiarity with single cell data analysis is preferred but not required.Familiarity with working on a computing cluster/server (important skills: Unix/Linux shell scripting)Experience designing computational methods and tools including prior experience with algorithms relevant to computational biology is a plus.Ability to work independently as well as part of an interdisciplinary team in a fast-paced environment while making necessary connections with experts in various computational analysis groupsSelf-starter highly motivated.Excellent organization and time management skills.The expected base pay range for this position as listed above is based on a 40 hour per week schedule. Broad provides pay ranges representing its reasonable and good faith estimate of what the organization reasonably expects to pay for a position at the time of posting. Actual compensation will vary based on factors including but not limited to relevant skills experience education qualifications and other factors permissible by law.At Broad your base pay is just one part of a comprehensive total rewards package. From day one this role offers a competitive benefits package including medical dental vision life and disability insurance; a 401(k) retirement plan; flexible spending and health savings accounts; at least 13 paid holidays; winter closure; paid time off; parental and family care leave; and an employee assistance program among other Broad benefits.The Broad Institute is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race national origin religion age color sex disability protected veteran status or any other characteristic protected by local state or federal laws rules or regulations.Should you need a reasonable accommodation to complete the application or interview process please contact for assistance.Required Experience:IC Key Skills Iis,Facilities Management,Access Control,Apache Web Server,High School,Flexcube Employment Type : Full Time Experience: years Vacancy: 1