Postdoctoral Research Fellow Lung Fibrosis at Mayo Clinic

DescriptionThe Haak and Tschumperlin labs at Mayo Clinic are seeking Postdoctoral Research Fellows to join our research groups for advanced training related to lung fibrosis and repair.Fellows will pursue NIH R01 funded basic and translational studies focused on fibroblast biology in the context of lung injury inflammation fibrosis and resolution. Our groups integrate mechanistic biology chemical biology and translational research to uncover how fibroblast subpopulations contribute to tissue pathology and to identify novel therapeutic strategies.Research Focus for Project 1:The molecular and functional roles of senescent fibroblasts in pulmonary fibrosisCrosstalk between senescent/inflammatory fibroblasts and alveolar epithelial cellsMechanisms linking aging tissue repair and fibroblast dysfunctionDiscovery characterization and validation of small-molecule modulators using in vitro ex vivo and in vivo modelsResearch Focus for Project 2:Define candidate transcriptional and epigenetic regulators of human fibroblast subpopulations in health and diseaseCreate advanced cell culture models to study fibroblast identity and plasticity as well as interactions with other relevant lung cell populationsDevelop nano-delivery strategies to modulate fibroblast functions in vivoKey Responsibilities:Design and execute in vitro and in vivo experiments related to fibroblast and lung biologyPerform and interpret molecular cellular and biochemical assaysWork with primary human and mouse fibroblasts alveolar epithelial cells co-culture models organoids and precision-cut lung slices and in vivo rodent models of lung fibrosis.Collaborate with medicinal chemists and drug discovery scientists to evaluate compound efficacyLead manuscripts present at conferences and contribute to grant progress reportsAssist in mentoring graduate studentsWhat We Offer:A collaborative environment with broad expertise in lung biology fibrosis and drug-discoveryOpportunity to work at the intersection of fibrosis cell and molecular biology and therapeutic developmentAccess to state-of-the-art core facilities and screening platformsProfessional development support for career advancementA robust training environment including potential eligibility for T32 support through our Translational Training in Respiratory Disease and Repair programQualificationsPhD or MD/PhD in cell biology molecular biology pharmacology biochemistry bioengineering or a related fieldStrong background in lung biology fibrosis cellular senescence or fibroblast biology.Demonstrated ability to independently design and perform experimentsStrong publication recordExcellent communication and teamwork skillsPreferred Skills:Fibroblastepithelial co-culture or organoid systemsSenolytics/senotherapeuticsSingle-cell or bulk transcriptomicsFibrosis models (bleomycin etc.)Mechanobiology or ECM remodelingHigh-content imaging or phenotypic screening Key Skills Virology,Bioinformatics,Genetics,R,Biochemistry,Cell Biology,Research Experience,Spectroscopy,Cell Culture,Molecular Biology,Microscopy,Research Laboratory Experience Employment Type : Full-Time Experience: years Vacancy: 1