Principal Scientist (Oligonucleotide Conjugation) at Amgen

Career CategoryScientificJob DescriptionJoin Amgens Mission of Serving PatientsAt Amgen if you feel like youre part of something bigger its because you are. Our shared missionto serve patients living with serious illnessesdrives all that we do.Since 1980 weve helped pioneer the world of biotech in our fight against the worlds toughest diseases. With our focus on four therapeutic areas Oncology Inflammation General Medicine and Rare Disease we reach millions of patients each year. As a member of the Amgen team youll help make a lasting impact on the lives of patients as we research manufacture and deliver innovative medicines to help people live longer fuller happier lives.Our award-winning culture is collaborative innovative and science based. If you have a passion for challenges and the opportunities that lay within them youll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.Principal Scientist -Oligonucleotide ConjugationWhat you will doLets do this. Lets change the world.Responsibilities:Design synthesize purify and analytically characterize oligonucleotide conjugates-including optimizing synthesis/conjugation/purification protocols.Drive technical execution of conjugation projects from start to finish and perform hands-on conjugate synthesis (developing and optimizing conjugation strategies and purification methods).Serve as the oligonucleotide conjugation subject-matter expert (SME) in cross-functional team meetings. Conduct biophysical/biochemical assays (e.g. ELISA SPR FRET BLI DSF DLS) to evaluate target binding and stability of oligonucleotide conjugates.Train as needed collaborate with the Genetic Medicines group and cross-functional teams to meet project objectives and timelines. Prepare research results for presentations patent applications and scientific publications. (This role supports Amgens pipeline of siRNA-based therapeutics.)Additional Responsibilities: Perform hands-on ligand linker/spacer and oligonucleotide synthesis at mg-to-gram scales including designing purifying analyzing synthetic products and optimizing synthetic protocols. Maintain detailed electronic lab notebooks and remain complaint on safety & required training.What we expect of youWe are all different yet we all use our unique contributions to serve patients. The qualified professional we seek is a Sr. Scientist with these qualifications.Basic Qualifications:Doctorate degree PhD OR PharmD OR MD and 2 years relevant experience orMasters degree and 5 years of relevant experienceBachelors degree and 7 years of relevant experiencePreferred Qualifications:Ph.D. in Chemistry Biochemistry Chemical Engineering or related discipline with 3-5 years experience in biotech/pharma plus specific experience in oligonucleotide conjugation e.g. designing synthesizing and characterizing oligo conjugates of small molecules linkers peptides proteins etc.Expertise in conjugation chemistries and site-specific bioconjugation techniques along with familiarity with RNA therapeutic modalities (ASO siRNA etc.).Proficiency in preparative and analytical chromatography techniques (IEX RP-HPLC SEC LCMS) for oligonucleotides and conjugates thereof is required.Experience with automated oligonucleotide synthesizers and associated processes (on-resin conjugation cleavage & deprotection desalting formulation) is a plus .Must demonstrate ability to conduct independent research and have strong communication/teamwork skills in a dynamic environment.What you can expect from usAs we work to develop treatments that take care of others we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture well support your journey every step of the way.The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to relevant skills experience and qualifications.In addition to the base salary Amgen offers a Total Rewards Plan based on eligibility comprising of health and welfare plans for staff and eligible dependents financial plans with opportunities to save towards retirement or other goals work/life balance and career development opportunities that may include:A comprehensive employee benefits package including a Retirement and Savings Plan with generous company contributions group medical dental and vision coverage life and disability insurance and flexible spending accountsA discretionary annual bonus program or for field sales representatives a sales-based incentive planStock-based long-term incentivesAward-winning time-off plansFlexible work models including remote and hybrid work arrangements where possibleApply now and make a lasting impact with the Amgen team.In any materials you submit you may redact or remove age-identifying information such as age date of birth or dates of school attendance or graduation. You will not be penalized for redacting or removing this information.Application deadlineAmgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.As an organization dedicated to improving the quality of life for people around the world Amgen fosters an inclusive environment of diverse ethical committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together we compete in the fight against serious disease.Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race color religion sex sexual orientation gender identity national origin protected veteran status disability status or any other basis protected by applicable law.We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process to perform essential job functions and to receive other benefits and privileges of employment. Please contact us to request accommodation. Amgen is an Equal Opportunity employer and will consider you without regard to your race color religion sex sexual orientation gender identity national origin protected veteran status or disability status..Salary Range139797.00 USD - 171340.00 USDRequired Experience:Staff IC Key Skills Machine Learning,Python,Data Science,AI,R,Research Experience,Sensors,Drug Discovery,Research & Development,Natural Language Processing,Data Analysis Skills,Toxicology Experience Employment Type : Full-Time Experience: years Vacancy: 1 Monthly Salary Salary: 171340 - 171340