Protein Structure Search & Design Intern at Syngenta Group

At Syngenta every employee plays a role in safely feeding the world and caring for our planet. Our Bioinformatics group in Durham North Carolina is seeking a Structural Bioinformatics Intern to advance protein discovery from metagenomic datasets. As part of a high-performance scientific team you will develop cutting-edge skills in structure-based protein search function prediction and computational design to deliver innovative solutions for agricultural biotechnology.Role PurposeApply structural bioinformatics methods to discover novel proteinsDevelop computational workflows that integrate sequence and structure-based search algorithms to identify and rank protein candidatesAccountabilitiesImplement protein structure-based search workflows using tools like FoldSeek ESMFold and BoltzPerform structural analysis and annotation of protein candidatesDevelop Python/Bash scripts for data processing and visualizationDocument workflows create user guides and present findings to cross-functional teamsCollaborate with other scientists to refine research strategies based on biological insightsShare results and learnings at team meetings and educate team members on workflows and resultsQualifications : RequirementsEducationCurrent MS or PhD student in Bioinformatics Computational Biology Structural Biology or related fieldTechnicalProficiency in Python and/or R for bioinformatics (PyRosetta a plus)Basic understanding of protein structure concepts (protein domains structural alignment)Familiarity of protein structure prediction methods (AlphaFold2 ESMFold Boltz)Familiarity with protein structure visualization (PyMOL or ChimeraX)Experience with Linux/Unix command-line environmentsKnowledge of sequence analysis tools (BLAST alignment methods)AnalyticalAbility to work with large datasets and implement reproducible computational workflowsStrong problem-solving skills and attention to detailEffective written and verbal communication skills Preferred Knowledge and SkillsExperience with protein structure comparison tools (TM-align FoldSeek)Experience with protein function prediction tools (InterProScan or ESM-based methods)Knowledge of protein databases (PDB UniProt AlphaFoldDB ESM Metagenomic Atlas)Experience with HPC or cloud computingSelf-motivated with ability to work independently and collaborativelyEnthusiasm for learning new computational methods and toolsExperience presenting technical work to diverse audiencesAdditional Information : Syngenta is an Equal Opportunity Employer and does not discriminate in recruitment hiring training promotion or any other employment practices for reasons of race color religion gender national origin age sexual orientation marital or veteran status disability or any other legally protected status. Syngenta has been ranked as atop employerby Science Journal. Learn more about ourteamand ourmission here:  Work : NoEmployment Type : Intern Key Skills Campaigns,Abinitio,AutoCAD 3D,Hardware & Networking,Customer Support,Arabic Experience: years Vacancy: 1