Quantitative Systems Pharmacologist at Pfizer

ROLE SUMMARY:Quantitative Systems Pharmacology (QSP) is a discipline that uses mechanistic mathematical models and disease platforms to enhance the robustness and quality of decision-making from exploratory research through clinical development. We are seeking a highly motivated individual to lead the development and application of QSP models for thein silico evaluation of novel targets and compounds including preclinical and clinical study design and mechanistic interpretation of results. The successful candidate will be responsible for integrating and sharing data and knowledge in a highly stimulating collaborative and multi-disciplinary environment to develop a deeper understanding of physiological systems and disease mechanisms across different therapeutic areas.ROLE RESPONSIBILITIES:Build and utilize QSP models of biological physiological and/or pathophysiological processes to evaluate novel targets pathways drug candidates to predict and interpret clinical response informing decision makingWork in close collaboration with biologists clinicians precision medicine scientists clinical pharmacologists pharmacometricians QSP and nonclinical modelers and other partner line colleagues to inform discovery and development programs and improve our understanding of disease mechanismsServe as QSP modeling & simulation expert in multidisciplinary project teams to solve challenging problems in drug discovery and development; contribute to preclinical and clinical study designs and mechanistic interpretation of dataDevelop and/or utilize state-of-the-art mathematical and computational tools to gain insight into causal relationships between individual components of targets pathways and system-level responsesAnalyze and interpret complex data sets in the context of disease mechanisms and pathways; develop a deep disease understanding and knowledgebaseBASIC QUALIFICATIONS:Ph.D. in Applied Mathematics Engineering Physics Pharmaceutical Sciences or related disciplines with strong background in mathematical statistical and numerical methods and 0 years of experienceExperience in developing QSP and/or differential equation-based models of biological or physiological systemsPREFERRED QUALIFICATIONS:Experience or strong interest in applying QSP approaches to drug discovery and development programs in the pharmaceutical industryExperience or interest in Oncology therapeutic areaDeep understanding of theory principles and statistical aspects of mathematical modeling and simulation including numerical methods parameter estimation/optimization ordinary differential equations (ODEs) and how these can be applied in the development of complex models of biological pathways and systemsComputational fluency and extensive hands-on experience with one or more modeling and simulation packages or programming languages (e.g. MATLAB R Julia SimBiology C/C)Creative and innovative scientist who is passionate about developing a deep understanding of disease and disease mechanisms and who hasexperience working closely with biologists clinical and nonclinical modelers and clinical colleaguesSelf-directed independent and highly motivated researcher who excels in a collaborative multi-disciplinary team environmentExcellent oral and written communication skillsPrimary authorship on relevant publications in peer-reviewed scientific journalsSelf-directed independent and highly motivated researcher who excels in a collaborative multi-disciplinary team environmentExcellent oral and written communication skillsPrimary authorship on relevant publications in peer-reviewed scientific journalsAdditional Job Details:Last date to apply is: December 15 2025The annual base salary for this position ranges from $102900.00 to $171500.00. In addition this position is eligible for participation in Pfizers Global Performance Plan with a bonus target of 15.0% of the base salary and eligibility to participate in our share based long term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of lifes moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution paid vacation holiday and personal days paid caregiver/parental and medical leave and health benefits to include medical prescription drug dental and vision coverage. Learn more at Pfizer Candidate Site U.S. Benefits (). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa FL or any location outside of the United States.Relocation assistance may be available based on business needs and/or eligibility.Sunshine ActPfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care providers name address and the type of payments or other value received generally for public disclosure. Subject to further legal review and statutory or regulatory clarification which Pfizer intends to pursue reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse your name address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter please do not hesitate to contact your Talent Acquisition representative.EEO & Employment EligibilityPfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race color religion sex sexual orientation age gender identity or gender expression national origin disability or veteran status. Pfizer also complies with all applicable national state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States. Pfizer endeavors to make to all users. If you would like to contact us regarding the accessibility of our website or need assistance completing the application process and/or interviewing please email. This is to be used solely for accommodation requests with respect to the accessibility of our website online application process and/or interviewing. Requests for any other reason will not be returned.Medical Key Skills Computer Science,Active Directory,Computer information Technology,PowerShell,OS,Windows,Database,SCCM,Linux,SAN,Troubleshoot,Backup,Setup,Technical Support,UNIX Employment Type : Full-Time Experience: years Vacancy: 1 Monthly Salary Salary: 102900 - 171500