Research Scientist II Cardiovascular Disease Initiative at The Broad Institute

General information Location Cambridge MA Ref # 43379 Job Family Research Date published 12/08/2025 Time Type Full time Pay Range 100000 - 140000 Usd Annual Description & Requirements The Broad Institute of MIT & Harvard a world leader in genetic research is looking for an exceptional candidate to join the Cardiovascular Disease Initiative (CVDi) led by Dr. Patrick Ellinor. The successful candidate will join an interdisciplinary team of computational biologists laboratory scientists and clinicians. The team works together to identify new genes associated with cardiovascular diseases including atrial fibrillation and heart failure and to then launch new therapeutic drug discovery programs based on these human genetic insights. CVDi project teams work closely with Center for the Development of Therapeutics (CDoT) to advance challenging projects using cutting-edge technologies. The candidate will work as a member of the Cardiovascular Disease Initiative to advance translational research projects. Specifically the candidate will conduct experimental research studies at the bench supervise a research associate and lead therapeutics project(s) targeting cardiovascular disease. Example workstreams for projects include: determining the cellular localization of a candidate gene by immunohistochemistry identifying interacting partners with the target protein assessing the suitability of the gene for assay development developing assays for small molecule hit identification validation and mechanistic characterization. The candidate will be responsible for developing characterizing and using in vivo models for target validation. This is an excellent opportunity for a highly motivated candidate interested in exploring the early stages of drug development in a vibrant atmosphere.Key responsibilitiesDesign and execute research plans to ensure that critical project requirements timelines and deliverables are met.Develop and execute cell-based assays to support target validation and hit identification & optimizationDevelop and execute in vivo mouse models and experiments to support target validationContribute to target validation using genomic perturbation techniques such as CRISPR siRNA etc.Support drug programs during the pre-clinical development stageTroubleshoot scientific problems with minimal guidanceAnalyze experimental data and communicate scientific results to team members and leadershipSupervise and mentor Research Associate(s) and junior team membersContribute to various research projects in a collaborative mannerREQUIREMENTSPh.D. in Biology (Developmental Molecular Cellular Biology) Biochemistry or related life science field with 2-5 years experience in an industrial or academic setting with a proven record of successful interaction with external collaborators and team membersHands-on experience in cellular assay development and proficiency with standard assay formats (e.g. imaging luminescence-/fluorescence-based cellular readouts immunohistochemistry Western blotting) in primary and cultured cellsExperience with mouse handling colony management and drug administration/dosing (IP IV SC RO gavage and blood collection)Experience with various cardiac mouse models and their characterization is preferred.Proficiency with echocardiography hemodynamics and surgery in rodents is a plusProficiency with tissue and cell based imaging techniques e.g. tissue sectioning staining histology confocal microscopy in situ hybridization is a plusExperience with cardiomyocyte-based assays such as calcium imaging contractility and in vitro modeling of cardiac disease is preferredExperience with induced pluripotent stem cell (iPSC) culture and cardiomyocyte differentiation is a plusProficient with standard cellular and molecular biology techniques such as qPCR western blot siRNA transfection viral transduction etc.Experience with CRISPR targeting technologies in primary cellsStrong understanding of cardiac biology and diseaseAbility to develop research plans for executing strategy operate and maintain equipment and perform laboratory work with complete independenceTrack record of working on complex problems and ability to integrate data from multiple disciplinesSupervising skills are a plusStrong interpersonal influencing and collaboration skills to work in a team-oriented matrix environment and the ability to work through conflictsOutstanding verbal and written communication abilitiesAbility to adapt to and effectively manage changes in a fast paced and dynamic environmentA passion and curiosity for science and sense of urgency to find new medicines to benefit patientsThe successful candidate will be a results-focused team-oriented creative bench scientist able to excel in a fast-track environment. The candidate must be self-motivated detail-oriented and exhibit strong problem solving addition the successful candidate should be a clear and effective communicator demonstrating strong interpersonal skills to enable collaboration with project teams peers and management for identifying and achieving research goals.The expected base pay range for this position as listed above is based on a 40 hour per week schedule. Broad provides pay ranges representing its reasonable and good faith estimate of what the organization reasonably expects to pay for a position at the time of posting. Actual compensation will vary based on factors including but not limited to relevant skills experience education qualifications and other factors permissible by law.At Broad your base pay is just one part of a comprehensive total rewards package. From day one this role offers a competitive benefits package including medical dental vision life and disability insurance; a 401(k) retirement plan; flexible spending and health savings accounts; at least 13 paid holidays; winter closure; paid time off; parental and family care leave; and an employee assistance program among other Broad benefits.The Broad Institute is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race national origin religion age color sex disability protected veteran status or any other characteristic protected by local state or federal laws rules or regulations.Should you need a reasonable accommodation to complete the application or interview process please contact for assistance. Key Skills Laboratory Experience,Machine Learning,Python,AI,Bioinformatics,C/C++,R,Biochemistry,Research Experience,Natural Language Processing,Deep Learning,Molecular Biology Employment Type : Full Time Experience: years Vacancy: 1