Scientist CMC at Empirico

Empirico a clinical-stage biotechnology company that combines unmatched expertise in human genetics-driven target discovery with world-class capabilities in siRNA medicines is seeking a chemist with an interest in solid-phase oligonucleotide synthesis and analytics. This is an excellent opportunity for a highly motivated creative scientist to be a vital member of our team.Responsibilities:You will be responsible for supporting the synthesis purification and characterization of oligonucleotides and their conjugates and optimizing methodologies to support the development of siRNA medicines. The ideal candidate will have experience in organic and analytical chemistry and both upstream and downstream oligonucleotide manufacturing processes. A key focus of this role will be developing scalable processes suitable for technology transfer to CDMOs. You will be expected to Perform solid-phase synthesis purification and characterization of oligonucleotidesDevelop and optimize scalable upstream (synthesis) and downstream (purification formulation) manufacturing processesSupport process development activities to enable successful technology transfer to CDMOsAnalyze interpret and clearly communicate synthetic and analytical dataPresent findings to senior staff and cross-functional teamsTroubleshoot and refine synthesis and purification protocolsManage multiple projects simultaneouslyRequirements:This position requires a BS in Chemistry with at least 7 years of relevant industry experience or an MS in Organic Chemistry Biochemistry or Chemical Engineering with a minimum of 3 years of experience or a PhD with at least 1 year of relevant experienceMinimum 1 year of experience working in a cGMP environmentHands-on proficiency with analytical instrumentation such as NMR LC-MS and RP-HPLC17 years of relevant work experience preferably in solid-phase oligonucleotide synthesis and familiarity with both upstream and downstream oligonucleotide manufacturing processesDemonstrated ability in analytical and purification method development using RPIP-HPLC AEX-HPLC UV MALDI and HRMSBackground in process development and technology transfer to CDMOs including development of scalable purification and formulation methodologiesWorking knowledge of tangential flow filtration (TFF) method developmentApplicants must have authorization to work in the U.S.The estimated annual base salary range for this role is $90000 to $120000. Individual compensation decisions will be based on various factors such as primary work location complexity and responsibility of role job duties/requirements and relevant experience and skills. We offer a wide range of benefits including a retirement savings plan (with company match) paid vacation holidays and health benefits to include medical prescription drug dental and vision coverage in accordance with the terms and conditions of the applicable plans.About Empirico: Empirico is a clinical-stage biotechnology company that discovers and develops siRNA medicines designed to mimic naturally-occurring genetic variants that confer beneficial effects on health and disease. Empiricos two foundational and proprietary technology platforms - the Precision Insights Platform for genetically-validated target discovery and the siRCH platform for the discovery and development of siRNA medicines - enable Empirico and its collaborators to rapidly advance programs from the discovery and validation of novel targets to clinically-viable therapeutics. Empiricos exceptional internal capabilities augmented by those of its partners are driving the advancement of a growing and differentiated pipeline of wholly-owned and partnered programs for a broad range of common diseases with unmet medical need. Empirico is headquartered in San Diego CA with a major second R&D site in Madison WI.Were striving to build a strong culture of inclusivity transparency and collaboration at Empirico where our diverse and equitable workforce is empowered to contribute to our mission. We always seek the best candidate for the position and encourage you to apply even if your experience or qualifications dont match up exactly with the job description. Empirico is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race color religion sex national origin sexual orientation gender identity disability status protected veteran status or any other characteristic protected by law.To All Agencies: Please do not contact any employee of Empirico about this position. All resumes submitted by agencies to any employee of Empirico via-email or in any form and by any method will be deemed the sole property of Empirico unless such agencies were engaged by Empirico for this position and a valid agreement is in place.We may use artificial intelligence (AI) tools to support parts of the hiring process such as reviewing applications analyzing resumes or assessing responses. These tools assist our recruitment team but do not replace human judgment. Final hiring decisions are ultimately made by humans. If you would like more information about how your data is processed please contact us. Key Skills Laboratory Experience,Immunoassays,Machine Learning,Biochemistry,Assays,Research Experience,Spectroscopy,Research & Development,cGMP,Cell Culture,Molecular Biology,Data Analysis Skills Employment Type : Full-Time Experience: years Vacancy: 1 Monthly Salary Salary: 90000 - 120000