SeniorPrincipal Research Associate, LNP DiscoveryPD at Fapon

Key Responsibilities:We are seeking a scientific contributor to lead and execute novel LNP formulation process development activity for the delivery of circular RNA therapeutic at scale. This role will spearhead LNP process development/scale up activity and would be responsible for designing and executing DOE-based formulation process optimization. They would engineer and functionalize LNPs develop analytics for formulation quality control and develop processes to improve formulation at scale. The candidate would have the opportunity to work in a collaboration-oriented role in which they would coordinate with other teams plan and run animal studies with a cross-functional group of scientists and support the growth and career development of junior scientists. The ideal candidate is a chemical engineer/pharmaceutical major with strong LNP formulation optimization and process development experience who is excited by the idea of being a core participant in building an early startup and guiding the scientific vision of the company. They would be engaged in science and driven by our mission to create therapies that help people in ways that are currently impossible.Establish execute and document protocols for preparation and characterization of targeted LNP formulations with nucleic acid cargo for in vitro and in vivo studiesDesign and execute DOE-driven studies for LNP composition mixing parameters and process optimization to improve formulation quality stability delivery efficiency and functional activityDevelop cell and molecular biology assays to assess the delivery efficiency of RNA cargo in mammalian primary cells to facilitate development of therapeutics drugs pipelinesAssist in the buildout of formulation and analytical capabilities with focus on delivery with nanoparticle technology lyophilization and process development for scale up/productionContribute to patent applications related to the delivery technologySupport technology transfer to CDMOs and Industry PartnersFoster collaborative relationships across the team and company and engage in a positive and exciting work environmentContribute to hiring training and collaborating with scientists (as needed) to formulate characterize develop and support assessment of efficacyPlan and coordinate animal studies with in vivo teamAuthor technical documents including SOPs for formulation processes and analytical methods maintain diligent records and demonstrate proficiency in scientific communicationSupport high-quality documentations to support regulatory filingsQualifications : Minimum Qualifications:BS/MS in chemical engineering chemistry pharmaceutical sciences or related field preferably with industry experience of 2-5 years for MS or 5-8 years for BS candidates.Strong track record of productivity in nanoparticle research with an understanding of key challenges in nanoparticle/formulation scale-up and translationPrior experience in developing lyophilization protocols for nanoparticle formulation and stability testing is a plusTechnical proficiency with LNP formulation of RNA and analytical assays for particle characterizationTechnical proficiency in developing cell and molecular biology assays to support drug product developmentA minimum of 3-4 years of experience working with lipid nanoparticles for RNA delivery in any capacityPreferred Qualifications:Demonstrated capability in LNP formulation for nucleic acid delivery is mustLNP process development and scale-up experience is desiredExperience with tissue-specific targeted delivery of LNP-nucleic acid formulation is a plusDemonstrated ability to present complex technical topics to a wide range of audiences with varying technical depthDemonstrated proficiency in record keeping and documentations to support SOP generation technology transfer and preferably regulatory filingsAdditional Information : What We Offer: At our RNA Venture we aim to outmatch the typical benefits you might see in an early startup. We offer:Financial security through competitive compensation incentives and retirement planHealth care and well-being programs including competitive medical dental vision & medical benefitsGenerous paid time off including vacation sick time holidays and winter shutdown401(k) retirement savings with a generous company matchCommuter benefitsOther comprehensive voluntary benefits include but are not limited to pet insurance life insurance employee assistance program (EAP) discount programs and many moreWe continue to optimize our benefits & wellness programs as we grow our organization to make sure they meet our diverse workforce needsThe stability of a startup backed by a company with a record of strong financial performance year over yearRemote Work : NoEmployment Type : Full-time Key Skills Laboratory Experience,Immunoassays,Mammalian Cell Culture,PCR,Biochemistry,Assays,Cell Biology,Research Experience,Cell Culture,Molecular Biology,Flow Cytometry,Western Blot Experience: years Vacancy: 1