SeniorPrincipal Scientist, Antibody Discovery at Nexagen Search

Senior/Principal Scientist Antibody Discovery Germantown MD Full Time Nexagen Searchis representing a biotechnology company that is hiring for an Senior/Principal Scientist Antibody Discovery to join their research team in Rockville MD. This role will contribute to early-stage discovery programs and will employ molecular biology biochemistry and cell-based techniques to support the development of novel therapeutic candidates.Key ResponsibilitiesLead discovery-stage research for pipeline therapeutic programs.Identify and validate novel antibody hits using phage/yeast display and/or hybridoma platforms.Develop and execute screening funnels to assess binding selectivity and functional activity across biochemical and cellular assays.Generate expression constructs and produce/purify candidate biologics in mammalian expression systems to support discovery workflows.Characterize antibody candidates through in vitro assays including binding analyses epitope assessment and functional cell-based readouts.Analyze and interpret experimental data to inform hit prioritization lead selection and next-step discovery strategies.Troubleshoot experimental challenges optimize assay conditions and refine discovery tools and methods.Present research findings to internal project teams and represent the program at scientific meetings as needed.Collaborate with cross-functional teamsincluding translational medicine medical sciences CMC and external CRO partnersto advance discovery candidates.May mentor or supervise research associates and scientists contributing to discovery programs.Core Qualifications & ExperiencePh.D. in biochemistry molecular/cell biology immunology pharmacology or related field.Deep expertise in antibody discovery technologies (eg. yeast/phage display hybridoma and/or single b-cell technologies)Hands-on proficiency with gene cloning library construction hit screening and initial lead characterization.Experience with biochemical and cell-based discovery assays such as FACS ELISA Octet and other quantitative binding/functional assays.Working knowledge of mammalian expression systems for producing and purifying screening-stage biologics.Experience running biophysical assays to evaluate KD binding kinetics and epitope interactions.Familiarity with different biologic formats applied in a discovery context.Highly collaborative mindset and ability to work effectively across multidisciplinary discovery teams.Strong written and verbal communication skills including clear presentation of complex scientific dataRecruiter in Charge:Jeff CaskeyManaging Partner Required Experience:Staff IC Key Skills Machine Learning,Python,Data Science,AI,R,Research Experience,Sensors,Drug Discovery,Research & Development,Natural Language Processing,Data Analysis Skills,Toxicology Experience Employment Type : Full Time Experience: years Vacancy: 1