Sr. Manager/Associate Director, Process Chemistry at Corvus Pharmaceuticals, Inc.

Department/Group:Chemistry
Location:South San Francisco, CA
Position Type:Full time

• Independently design synthetic strategies and use those strategies to synthesize and characterize precursor compounds, starting materials, intermediates, reference compounds, and new chemical entities
• Scale up and process development of small molecules across early through late-stage phases
• Design and conduct control strategies for drug substance manufacturing including impurity identification and synthesis, and fate and purge experiments
• Purify and characterize molecules with standard analytical techniques (e.g. HPLC, LCMS, NMR)
• Collaborate with cross functional teams of product development, QA, analytical and formulations.
• Work with contract organizations and support technology transfer
• Perform research and/or development in collaboration with others in chemistry and biology; make detailed observations and analyze data.
• Prepare batch records, technical reports, summaries, protocols and quantitative analyses
• Write and review manuscripts for publication
• Provide support in corporate research and development of patent applications
• Develop strategies to ensure effective achievement of scientific objectives
• Uses skills to contribute to development of company objectives and principles and to achieve goals in creative and effective ways
• Exercises independent judgment in selecting methods, techniques and evaluation criteria for obtaining results

• PhD in Chemistry plus 5+ years of related experience in pharmaceutical or biotechnology industry or equivalent.
• Demonstrated expertise and hands on experience in synthetic organic chemistry process development and manufacturing.
• Knowledge of regulatory (ICH, USP etc.) standards.
• Experience working with CRO/CDMO partners for drug substance manufacturing.
• Must possess expert knowledge of scientific principles and concepts.
• A solid understanding of modern analytical techniques (NMR, HPLC, MS)
• Excellent verbal and written communication skills and the ability to collaborate effectively within a multidisciplinary team

• Able to manage outside vendor collaborations
• Flexibility and willingness to solve problems that fall outside of immediate area of expertise
• Work independently in an interdisciplinary, fast paced, often changing environment.
• Committed to the values of integrity, accountability, transparency, and drive.